What is Tadalafil (Cialis)

Many people freak out on Viagra, while some go totally gung ho on Cialis; may be it is all about the basic human taste, you love ice-cream, well, and I’d rather munch those cookies. Tadalafil is contraindicated in men for whom sexual intercourse is inadvisable due to unstable cardiovascular disease (e.g. patients with unstable angina and severe congestive heart failure) (see Section 4.4 Special Warnings and Precautions for Use).
The use of ED drugs is not recommended in men who have a recent history of stroke or myocardial infarction (within the last 6-8 weeks), or who have significantly low 犀利士 blood pressure, uncontrolled high blood pressure, unstable angina, severe cardiac failure, severe liver impairment or end-stage kidney disease requiring dialysis.

Cranberry juice may also decrease how quickly medications such as warfarin are broken down by the liver, and this is another way it may affect the INR, or International Normalized Ratio, which is used to determine how much warfarin should be given to a person each day.
Two of these studies were in men with BPH and one study was specific to men with both ED and BPH see Clinical Studies The first study (Study J) randomized 1058 patients to receive either CIALIS 2.5 mg, 5 mg, 10 mg or 20 mg for once daily use or placebo.

Also, patients with ED in all severity categories reported improved erections while taking tadalafil 20 mg (86%, 83% and 72% for mild, moderate and severe, respectively) compared to patients on placebo (45%, 42% and 19% for mild, moderate and severe, respectively).
In this erectile dysfunction and benign prostatic hyperplasia study, Cialis 5 mg demonstrated statistical superiority over placebo for total IPSS (mean treatment difference, -2.3; p < 0.001) and for the International Index of Erectile Function Erectile Function (IIEF EF) domain score (mean treatment difference, 4.7; p < 0.001).
In patients with mild or moderate hepatic impairment, the dose of CIALIS should not exceed 10 mg. Because of insufficient information in patients with severe hepatic impairment, use of CIALIS in this group is not recommended see Use In Specific Populations.

The efficacy and safety of CIALIS for once daily use for the treatment of ED, and the signs and symptoms of BPH, in patients with both conditions was evaluated in one placebo-controlled, multinational, double-blind, parallel-arm study which randomized 606 patients to receive either CIALIS 2.5 mg, 5 mg, for once daily use or placebo.
Tadalafil exaggerates the increases in heart rate and lowering of blood pressure caused by nitrates , for example, nitroglycerin , isosorbide dinitrate ( Isordil ), isosorbide mononitrate (Imdur, Ismo, Monoket ), nitroglycerin ( Nitro-Dur , Transderm-Nitro) that are used primarily for treating heart pain ( angina ). In patients who take nitrates for angina , tadalafil could cause heart pain or possibly even a heart attack by exaggerating the increase in heart rate and the lowering of blood pressure Therefore, tadalafil should not be used with nitrates.

Effects on Cardiac Electrophysiology: The effect of a single 100-mg dose of tadalafil on the QT interval was evaluated at the time of peak tadalafil concentration in a randomized, double-blinded, placebo, and active (intravenous ibutilide) -controlled crossover study in 90 healthy males aged 18 to 53 years.
Cialis must not be taken with nitrates (a type of medicine used for angina) or medicines of the class ‘guanylate cyclase stimulators’ such as riociguat (a medicine for high blood pressure in the vessels supplying the lungs, known as pulmonary hypertension).

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